看起來 ADI-PEG 20 在 AML 也有不錯的效果

7vimg3ve58 · 2025-11-14T17:44:04Z

ASH 2025 posters preview https://www.eurekalert.org/news-releases/1105965 Results of the Phase 1B study of pegargiminase (ADI-PEG 20) in combination with AZA-VEN in newly diagnosed high-risk AML patients not candidates for intensive chemotherapy Of these, 16 had best response of CR (69.6%), 1 CRh (4.3%), 4 CRi (17.4%), and 2 MLFS (8.7%), resulting in an objective response rate (CR+CRh+CRi; composite CR [CRc]) of 91.3% (21/23). Median OS was 19.1 months (95% CI: 7.8-NR), and 14/23 pts (60.9%) were censored for OS analysis (still alive). 只用AZA+VEN OS 約14.7個月

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